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For patients who were receiving Trulicity for its cardiovascular risk reduction benefits (as demonstrated in the REWIND trial for adults with type 2 diabetes at high cardiovascular risk), discontinuation means this protection may be lost

What was once viewed primarily as a gut-pancreas hormonal axis for postprandial glucose regulation has now emerged as a central therapeutic pathway influencing inflammation, cardiovascular function, renal and hepatic systems, and even neuroendocrine regulation

Longer-term data and more studies would help reduce my concerns

A greater impact was observed in the metabolic syndrome associated with MASLD with the SEMA-RM-LNC than with the RM-LNC or Rybelsus , in suspension form